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a big difference, in my view.. playing strong nt, the nt hand is more likely to want the lead coming to it, so it's more important to make that hand declare
Right-siding the contract is overrated as a reason to play transfers. Even opposite a strong NT this is worth a very small fraction of a trick on average at best. The main reason behind transfers is for improved constructive bidding; giving up the diamond suit at the 2 level gives you many more major suit oriented sequences. So they are still useful over weak NTs.
The reason not to play transfers is that in theory they are easier to defend against. Over the transfer you give RHO many more sequences, as he can pass then bid, double then bid, bid directly, or cue. Whereas if you bid the signoff directly he can only pass, double, bid. But in my experience no one has really taken advantage of this weakness, so it's probably right to play transfers for their constructive bidding advantages.

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